OPD Syndrome
Family Resource Network
General Information
OPD II is more severe than OPD I and has more abnormalities associated with it. There
world. Of course, there may be many more cases that are as yet undiagnosed.

The label Oto Palatal Digital simply describes the characteristics of the syndrome. Oto
refers to the conductive hearing loss associated with OPD, palatal refers to the cleft
soft palate which is common and digital refers to the abnormalities of the fingers and
toes of an affected child. There are also other characteristics, some which are common
and some that are quite rare or, at least, somewhat unknown to be connected with OPD.
For instance, although there are bone abnormalities associated with most cases of OPD,
some children also have severe scoliosis, which is not necessarily associated with OPD.
Some children with OPD have what is known as Arnold Chiari malformation but for others,
this is not the case. Obviously, OPD manifests slightly differently in each child.

There are quite a few articles listed on the articles page that present different cases
physicians have seen, however, there seems to be very little actual research on OPD. In
relatively recent articles though, OPD seems to have been compared to Mellnick Needles
similar syndromes and not really a completely separate entity. Below is a list of the
common characteristics of both OPD I and OPD II.

*Listed below are various synonyms of Oto Palato Digital Syndrome Type I and II
Andre Syndrome
Cranioorodigital Syndrome
Digito-Oto-Palatal Syndrome
Faciopalatoosseous Syndrome
OPD Syndrome
Otopalatodigital Syndrome
Palato-Oto-Digital Syndrome
Taybi Syndrome
~frontal bone prominence
cleft palate
~downward slanting palpebral fissures
~conductive hearing loss
~shortness of fingers and toes
~short stature
hypoplastic facial bones (underformed with lack
of normal function)
~broad bridge of the nose
~short broad thumbs and great toes
~wide spaces between toes
~short fingernails
~dislocation of the
head of the radius (near elbow
~slow speech development due to hearing loss
and in rare cases, mild retardation

*Females affected with the syndrome show milder
~broad forehead
~downward slanting
palpebral fissures
~flat bridge of the nose
~small mouth
cleft palate
~flexed and overlapping short fingers
~short toes
~bowing of the long bones of arms and legs
~occasional mild retardation

*Females affected with OPD-II show milder
signs and symptoms.